FOR EVERY INDUSTRIAL PROCESS
ASPIDIA offers chemical industries a service for research, optimization and production of enzymes for industrial processes, including bioremediation.
With its experts, in collaboration with prestigious Italian and European universities, ASPIDIA uses bioinformatic analysis of enzyme sequences from different organisms but performing the same biochemical function, to provide information on conserved protein sites essential for enzyme activity and variable regions that may modulate affinity for different substrates.
Molecular modeling based on the enzyme's functional site and interaction with the target substance allows the design of ad hoc modifications in the binding site sequence to suit the specific chemical to be treated.
Once candidate enzymes are defined, they are made to express, by genetic engineering, in microorganisms chosen as optimal biofactors, purified, and tested for their biochemical efficacy.
ASPIDIA can reliably and effectively help you identify the most suitable enzymes, performing custom optimization, for new bioremediation and transformation processes for specific industrial needs.
By identifying enzymes tailored to the specific industrial process, you can achieve reduced operating costs and the implementation of sustainable, green infrastructure at limited fixed costs.
Bioinformatic analysis of enzyme sequences, from different organisms but performing the same biochemical function, provides information on conserved protein sites essential for enzyme activity and variable regions that may modulate affinity for different substrates.
Bioremediation, which involves the use of a biological agent to degrade contaminants, is an environmentally friendly and sustainable approach that can destroy a pollutant or convert harmful contaminants into harmless substances. It could effectively and affordably combat per- and polyfluoroalkyl substances (PFAS) contamination of environmental matrices. However, the ability of biological agents to degrade PFAS is still poorly studied.
ASPIDIA has developed a research project based on the enzyme dehalogenase, which has been shown to be capable of biodegrading perfluorooctanoic acid. The recombinant dehalogenase enzyme, overexpressed in suitable microorganisms, could therefore be useful in bioremediation activities of PFAS-contaminated matrices.
Previous studies show that bioremediation is feasible and that our technology is appropriate.
Biological breakdown of the stable structure of PFASs and removal of fluorine atoms could allow significant improvement in reducing the environmental toxicity of PFASs, reduce the cost of PFAS removal/destruction ensure the removal of PFASs from the environment.